Angular right symmetricity of bounded linear operators on Hilbert spaces

We introduce and characterize angular right symmetric and approximate angular right symmetric points of the algebra of all bounded linear operators defined on either real or complex Hilbert spaces

Lessons learned from SARS-CoV and MERS-CoV : FDA-approved Abelson tyrosine-protein kinase 2 inhibitors may help us combat SARS-CoV-2

SARS-CoV-2 is a newly emerging infectious disease, which originated from Wuhan in the Hubei province of China in late December 2019 [1]. Since then, it has rapidly spread all over the world, and at the time of writing this letter, WHO statistics show more than 1,696,588 cases and 105,952 deaths confirmed across the world [2]. Although there is no specific therapy for SARS-CoV-2 infection [3], combination therapy with antiviral and anti-inflammatory drugs accompanied by supportive treatment have been used for SARS-CoV-2 patients [4]. The combination of well-known HIV protease inhibitors, such as ritonavir with lopinavir, has also been a common approach to treat SARS-CoV-2. Insufficient outcome in severe cases is, however, one of the main challenges associated with the current antiviral-based therapy for SARS-CoV-2 [5]. In view of the long period required for novel drug discovery and the desperate need for a prompt response to this pandemic infection, one must resort to repurposing FDA-approved drugs. In this direction, our experience with other close members of coronaviruses such as SARS and MERS has taught us that repurposing the current drugs is a reasonable strategy. Abelson tyrosine-protein kinase 2 (Abl2), the imatinib target, was required for efficient SARS-CoV and MERS-CoV replication in vitro [6]. Coleman et al. have shown that the imatinib target Abl2 is indispensable for efficient replication of SARS-CoV and MERS-CoV in vitro

High-potency ligands for DREADD imaging and activation in rodents and monkeys

Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are a popular chemogenetic technology for manipulation of neuronal activity in uninstrumented awake animals with potential for human applications as well. The prototypical DREADD agonist clozapine N-oxide (CNO) lacks brain entry and converts to clozapine, making it difficult to apply in basic and translational applications. Here we report the development of two novel DREADD agonists, JHU37152 and JHU37160, and the first dedicated 18F positron emission tomography (PET) DREADD radiotracer, [18F]JHU37107. We show that JHU37152 and JHU37160 exhibit high in vivo DREADD potency. [18F]JHU37107 combined with PET allows for DREADD detection in locally-targeted neurons, and at their long-range projections, enabling noninvasive and longitudinal neuronal projection mapping

Defects in Zeolite Catalysts and Membranes

ZSM-5 is one of the most well-known zeolites. It has been synthesized for many different applications, including as catalyst for catalytic reactions and as a membrane in separation processes.  The main goal of this thesis is to investigate and characterize the defects in crystal and film growth of ZSM-5 for modification purposes. Primarily, ZSM-5 crystals with carefully controlled thickness were synthesized in fluoride and hydroxide media. These synthesized catalysts were then characterized and the two synthesis routes were compared with each other in terms of stability. Then, in the synthesized catalysts, the role of defects during reaction was investigated. Furthermore, the growth of ZSM-5 nanocrystals and subsequent film formation was investigated to better understand how particles formed in synthesis solution (a hydrolyzed mixture of H2O-TEOS-TPAOH), followed by how these crystals interact to form a zeolite film. Finally, pre- and post-production modification of ZSM-5 and PHI membranes was investigated. Since, the roughness surface of the support could play a crucial role in having an even film, it was done as a pre-treatment technique for membrane synthesis. Additionally, a technique was developed in an attempt to plug the defects of grain boundaries to increase the membrane performance.

On Approximate Birkhoff-James Orthogonality and Approximate astast-orthogonality in CastC^ast-algebras

We offer a new definition of $varepsilon$-orthogonality in normed spaces, and we try to explain some properties of which. Also we introduce some types of $varepsilon$-orthogonality in an arbitrary  $C^ast$-algebra $mathcal{A}$, as a Hilbert $C^ast$-module over itself, and investigate some of its properties in such spaces. We state some results relating range-kernel orthogonality in $C^*$-algebras

An Investigation of Predictors of Life Satisfaction among Overseas Iranian Undergraduate Students

In recent years, many young people have gone overseas to study and live at least temporarily in new countries that maybe quite different to their homeland. The aim of this study was to determine the predictors of life satisfaction among Iranian undergraduate students studying at Malaysian private universities. A total of 361 undergraduate students were identified as respondents of this study by using Multi-Stage random sampling technique. The results of the study showed that the Iranian undergraduate students were moderately satisfied with their overseas student life. Findings also showed that the results of multiple regression analyses indicated social support emerged as the strongest unique predictor of life satisfaction, followed by academic achievement, and adjustment. Findings revealed that 44.8% of the variability in life satisfaction could be predicted by social support, academic achievement, and adjustment. The results also indicated that social support significantly mediated the effect of loneliness on life satisfaction